Honeycomb in Medicine

The hexagonal honeycomb made by bees to contain their larvae and store honey and pollen has long been admired as one of nature's architectural marvel.

Picture of honeycombs

Note that the surface of honeycombs have a characteristic texture that looks like gaps or air spaces separated by thick segments.

In fibrosis of the lungs,the lung tissue becomes damaged and scarred. The fibrotic lungs exhibit a similar appearance with variable sized cystic air spaces separated by thick fibrotic walls as depicted in the image below.

https://www.flickr.com/photos/pulmonary_pathology/13436105903

This gross appearance can also be visualised radiographically by CT imaging of the lungs as seen in the below image.

https://in.pinterest.com/pin/379428337355530820/

Note:

-The walls of the air spaces are lined by bronchiolar epithelium and the spaces are often filled with mucin and inflammatory cells. 

Suggested references:

radiopaedia.org_honeycombing lungs

uspharmacist.com_causes of pulmonary fibrosis

slide share link_causes of pulmonary fibrosis

clinical features_pulmonary fibrosis
Pathophysiology of the lung in pulmonary fibrosis